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Time course of antibody formation to hFIX. Rabbits were injected with (a,b) AAV-2 or (c,d) AAV-8 at doses of 1 × 1012 vg/kg (low dose) or 1 × 1013 vg/kg (high dose). The data are shown for each individual animal. *Animals that developed inhibitory antibodies against hFIX.