Figure 5.

Long-term follow-up of semen analysis for vector DNA from AAV-injected rabbits as a function of spermatogenesis cycles. Percentage of rabbits that exhibited at least one positive semen sample for AAV vector DNA. Rabbits received AAV-2 (n = 10) or AAV-8 (n = 9) at doses of 1 × 10¹² vg/kg (low dose) or 1 × 10¹³ vg/kg (high dose). The last positive semen samples for AAV-2 injected rabbits were collected at day 56 (low dose) and day 104 (high dose). For the AAV-8 injected rabbits the last semen sample containing vector DNA was from day 70.