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. 2009 May 12;17(8):1442–1452. doi: 10.1038/mt.2009.102

Figure 4.

Figure 4

Microenvironment-induced depletion of lymphocytes after bone marrow transplantation and AdShhN treatment. Naive (untreated) B6.SJL mice were lethally irradiated and transplanted with bone marrow cells from C57BL/6 mice treated 18 days before with either phosphate-buffered saline (PBS), AdNull, or AdShhN (PBS cells, n = 4; AdNull cells, n = 4; AdShhN cells, n = 5) (a) or C57BL/6 mice were lethally irradiated and transplanted with cells from naive B6.SJL mice and treated with either PBS (n = 6), AdNull (n = 6), or AdShhN (n = 5) (b–d). (a) Peripheral blood cell counts 8 weeks after transplantation in mice transplanted with cells from PBS-, AdNull-, or AdShhN-treated donors (see Figure 3c for experimental design); (b) schematic representation of the experimental design of bone marrow transplantation and treatment of recipients with PBS, AdNull, or AdShhN; (c) percentage of donor cells in different lineages in peripheral blood 5 and 8 weeks after transplantation and in bone marrow 10 weeks after transplantation in recipients treated with PBS, AdNull, or AdShhN; and (d) peripheral blood cell counts 8 weeks after transplantation in recipients treated with PBS, AdNull, or AdShhN. Data shown as mean ± SE. Ad, adenovirus; Shh, Sonic hedgehog.