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. 2009 May 26;17(8):1395–1403. doi: 10.1038/mt.2009.92

Figure 3.

Figure 3

Converted marker expression by MM cells after cell-mediated transfer of MV-λ infection. (a) MV-λ infected nonplasma cells [mature dendritic cell (MDC), U-937 monocytes, and Jurkat T cells] secreted only free λ chain, while κ was not detectable (ND) in enzyme-linked immunosorbent assay. (b) Cell carrier transfer of MV-λ infection to MM cells resulted in expression of recombinant IgG-κ/λ. (c) Infected carriers mixed with KAS-6/1 cells produced both κ and λ proteins after 24 hours and 72 hours of incubation. (d) MV-λ infection converted myeloma IgG into a double positive IgG-κ/λ, while λ chain was not detected in control uninfected KAS-6/1 cells. Data are from one of three experiments with MDCs collected from different donors.