Fig. 2.
NO derived from iNOS activity induces a punctate nuclear Zn2+-specific fluorescence activity. Fluorescence and transillumination micrographs of nuclei of cytokine-activated WT MAEC cultured in the absence (A–C) or presence (E)of250 μM of the iNOS-specific inhibitor l-NIO. A line scan through the nuclei was performed at 500 nm (D and F), confirming the nuclear punctate-staining pattern against a more diffuse nuclear background. [Scale bars represent 0.5 nm (A and B) or 0.75 nm (C and E).]