The effect of glial inhibitors on IL-1β-induced orofacial hyperalgesia. IL-1β (160 fmol) was injected into the ventral Vi/Vc. Fluorocitrate (A) (FC, 120 pmol), minocycline (B) (MC, 200 pmol), and propentofylline (C) (PPF, 10 pmol) was injected into the ventral Vi/Vc at 10 min prior to IL-1β injection. Pretreatment with fluorocitrate, minocycline and propentofylline did not prevent IL-1β-induced hyperalgesia. *, +: p<0.05; **, ++: p<0.01 (ANOVA with repeated measures and post-hoc test).