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. Author manuscript; available in PMC: 2010 Mar 9.
Published in final edited form as: Stat Biopharm Res. 2009 Aug 1;1(3):213–228. doi: 10.1198/sbr.2009.0014

Table 3.

Horizontal and (expressed as percent) vertical bias and absolute error, and percentage of runs where MTD estimate misses target by ≥ 0.5, for frequentist MTD estimation.

Average bias
Average absolute error
Condition Horizontal Vertical Horizontal Vertical % of runs where |h*h| ≥ 0.5
All runs 0.07 2.1 0.42 7.4 26.7
h = 2 0.00 0.6 0.33 5.6 20.0
h = 3.5 0.07 1.8 0.40 6.9 24.9
h = 5 0.14 3.8 0.53 9.8 35.1
b = 0.7 0.12 2.6 0.56 7.6 39.2
b = 1.4 0.02 1.6 0.28 7.3 14.1
v = 0.5 0.03 0.8 0.30 5.2 17.3
v = 0.95 0.12 3.3 0.54 9.6 36.1
M = 0.2 0.05 2.0 0.45 7.0 30.0
M = 1/3 0.09 2.2 0.39 7.9 23.3
n = 25 0.09 3.0 0.53 9.3 33.0
n = 50 0.06 1.6 0.37 6.5 20.3
Q = 0.2 −0.02 0.4 0.33 5.7 21.7
Q = 0.6 0.16 3.8 0.51 9.2 31.6
L = 1 0.07 2.1 0.42 7.4 26.2
L = 3 0.07 2.1 0.42 7.5 27.1