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In vitro characterization of genetic polymorphisms in NTCP
In vitro function was assessed using prototypical substrates for NTCP (taurocholate and cholate). Data are from Ho et al. (2004).
| Nucleotide Change | Amino Acid Change | In Vitro Function | Protein Expression/Localization |
|---|---|---|---|
| SLC10A1 | NTCP | ||
| T668C | I223T | ↓ | Intracellular |
| C800T | S267F | ↓ | Normal |
| T836C | I279T | ↓ | Normal |
| A940G | K314E | ↓ | Normal |
↓, reduced function.
