TABLE 2.
Subcellular localization of uptake OATP/Oatp transporters in various species
For each transporter, the apical or basolateral localization in a particular tissue and/or species is provided. Species included rat (R), mouse (M), human (H), and bovine (B). Detailed information regarding particular cellular populations or regions of the tissue are provided for some transporter isoforms.
| Cellular Localization | Tissue | Species | Cell Types | References |
|---|---|---|---|---|
| Oatp1a1 | ||||
| Basolateral | Liver | R | Hepatocytes | Eckhardt et al., 1999 |
| Apical | Kidney | R | Proximal tubule cells | Bergwerk et al., 1996 |
| Apical | Choroid plexus | R | Epithelial cells | Angeletti et al., 1997 |
| Oatp1a4 | ||||
| Basolateral | Liver | R | Hepatocytes (midzonal to centrilobular) | Kakyo et al., 1999; Reichel et al., 1999 |
| Basolateral | Choroid plexus | R | Epithelial cells | Gao et al., 1999 |
| Basolateral | Brain | R | Capillary endothelial cells | Roberts et al., 2008 |
| Apical | Eye | R | Retinal pigment epithelium | Gao et al., 2002; Ito et al., 2002 |
| Oatp1a5 | ||||
| Apical | Choroid plexus | M | Epithelial cells | Ohtsuki et al., 2004b |
| Apical | Brain | M | Capillary endothelial cells | Ohtsuki et al., 2004b |
| Apical | Jejunum | R | Enterocytes | Walters et al., 2000 |
| N.D. | Eye | R | Nerve fiber, ganglion cells | Ito et al., 2002 |
| Oatp1b2 | ||||
| Basolateral | Liver | R | Hepatocytes | Cattori et al., 2001 |
| Oatp2a1 | ||||
| N.D. | Kidney | R | Glomeruli, endothelial cells, collecting ducts | Bao et al., 2002 |
| Oatp2b1 | ||||
| Basolateral | Brain | R | Capillary endothelial cells | Roberts et al., 2008 |
| Apical | Choroid Plexus | R | Epithelial cells | Roberts et al., 2008 |
| Oatp3a1 | ||||
| N.D. | Heart | R | Aorta endothelial cells | Adachi et al., 2003 |
| N.D. | Lung | R | Alveolar epithelial cells | Adachi et al., 2003 |
| N.D. | Trachea | R | Mucosal epithelium | Adachi et al., 2003 |
| N.D. | Testes | R | Spermatozoa tails | Adachi et al., 2003 |
| N.D. | Ovary | R | Oocytes and smooth muscle cells | Adachi et al., 2003 |
| N.D. | Uterus | R | Glandula uterine epithelium, smooth muscle cells of myometrium, surface epithelium of endometrium | Adachi et al., 2003 |
| N.D. | Kidney | R | Distal tubules and collecting ducts | Adachi et al., 2003 |
| Oatp4a1 | ||||
| N.D. | Eye | R | Corneal epithelium, ciliary body, iris, retina | Ito et al., 2003 |
| Oatp4c1 | ||||
| Basolateral | Kidney | R | Proximal tubule cells | Mikkaichi et al., 2004 |
| OATP1A2 | ||||
| Apical | Liver | H | Cholangiocytes | Lee et al., 2005a |
| Apical | Small Intestine | H | Enterocytes at the villus tip | Glaeser et al., 2007 |
| Apical | Kidney | H | Distal tubules | Lee et al., 2005a |
| N.D. | Brain | H | Capillary endothelial cells | Lee et al., 2005a |
| OATP1B1 | ||||
| Basolateral | Liver | H | Hepatocytes | Cui et al., 2003 |
| OATP1B3 | ||||
| Basolateral | Liver | H | Hepatocytes (centrilobular) | Cui et al., 2003 |
| OATP1C1 | ||||
| N.D. | Testes | H | Leydig cells | Pizzagalli et al., 2002 |
| OATP2B1 | ||||
| Basolateral | Liver | H | Hepatocytes | Grube et al., 2006a |
| Basolateral | Placenta | H | Syncytiotrophoblasts | St-Pierre et al., 2002; Grube et al., 2007 |
| Apical | Small Intestine | H | Enterocytes | Kobayashi et al., 2003 |
| N.D. | Heart | H | Vascular endothelium | Grube et al., 2006a |
| OATP4A1 | ||||
| Apical | Placenta | H | Syncytiotrophoblasts | Sato et al., 2003 |
N.D., not determined.