TABLE 9.
Subcellular localization of bile acid, cholesterol, aminophospholipid, and copper transporters in various species
For each transporter, the apical or basolateral localization in a particular tissue and/or species is provided. Species included rat (R), mouse (M), human (H), and bovine (B). Detailed information regarding particular cellular populations or regions of the tissue are provided for some transporter isoforms. N.D., not determined.
| Cellular Localization | Tissue | Species | Cell Types | References |
|---|---|---|---|---|
| Ntcp | ||||
| Basolateral | Liver | M, R, H | Hepatocytes | Stieger et al., 1994; Keitel et al., 2005; Aleksunes et al., 2006 |
| Apical | Pancreas | R | Acinar cells | Kim et al., 2002a |
| Asbt | ||||
| Apical | Ileum | M | Enterocytes | Dawson et al., 2005 |
| Apical | Kidney | R | Proximal convoluted tubules | Christie et al., 1996 |
| Apical | Liver | R | Cholangiocytes | Lazaridis et al., 1997 |
| Bsep | ||||
| Apical | Liver | M, R, H | Hepatocytes | Childs et al., 1998; Jansen et al., 1999; Green et al., 2000 |
| Ostα | ||||
| Basolateral | Ileum | M, R, H | Enterocytes | Ballatori et al., 2005; Dawson et al., 2005 |
| Basolateral | Liver | M, H | Hepatocytes, cholangiocytes | Ballatori et al., 2005 |
| Basolateral | Kidney | M, R, H | Proximal tubule cells | Ballatori et al., 2005 |
| Ostβ | ||||
| Basolateral | Ileum | M, H | Enterocytes | Ballatori et al., 2005; Dawson et al., 2005 |
| Abcg5 | ||||
| Apical | Liver | M, H | Hepatocytes, cholangiocytes | Graf et al., 2003; Klett et al., 2004a |
| Apical | Small intestine | M, H | Enterocytes | Graf et al., 2003; Klett et al., 2004a |
| Intracellular | Gallbladder | H | Mucosal epithelial cells | Klett et al., 2004a |
| Abcg8 | ||||
| Apical/Intracellular | Liver | H | Hepatocytes, cholangiocytes | Klett et al., 2004a |
| Apical | Small intestine | H | Enterocytes | Klett et al., 2004a |
| Intracellular | Gallbladder | H | Mucosal epithelial cells | Klett et al., 2004a |
| ATP7B | ||||
| Apical | Liver | R | Hepatocytes | Hernandez et al., 2008 |
| Apical | Placenta | H | Syncytiotrophoblasts | Hardman et al., 2004; Hardman et al., 2007 |
| Intracellular | Small intestine | M | Enterocytes | Weiss et al., 2008 |
| Intracellular | Mammary gland | M | Ductal epithelial cells | Michalczyk et al., 2000 |
| ATP8b1 | ||||
| Apical | Liver | M, R, H | Hepatocytes | Eppens et al., 2001; Ujhazy et al., 2001 |
| Apical | Small Intestine | R | Enterocytes | Ujhazy et al., 2001 |