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Quantitative analysis of lesion volume in control (OVX), rtPA (10 mg/kg), and E2 (100 μg/kg) + rtPA (10 mg/kg) group at 24 h after transient focal MCAO by suture. E2 treatment in combination with rtPA (E2 + rtPA) significantly (p < 0.05) reduced ischemic lesion volume, compared with rtPA treatment alone (rtPA) and control treatment.
