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. 2010 Mar;332(3):1006–1012. doi: 10.1124/jpet.109.160937

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Fig. 4. — A, representative plasminogen-dependent casein zymogram of control, rtPA, and E2 + rtPA group at 24 h after transient focal MCAO by suture. A dramatic increase of uPA activity was shown in the ischemic side, which was attenuated by E2 treatment. The lytic zones of tPA (64 kDa) and uPA (48 kDa) were quantitatively analyzed. Normalized values of tPA (B) and uPA (C) expressed as 100% of nonischemic hemisphere in controls (Ctl). ∗, p < 0.05 versus nonischemic hemisphere in controls. #, p < 0.01 versus rtPA group.