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. 2010 Mar;332(3):1006–1012. doi: 10.1124/jpet.109.160937

Fig. 5.

Fig. 5.

A, representative Western blots of MMP2 and MMP9 in control, rtPA, and E2 + rtPA group at 24 h after transient focal MCAO by suture. Dramatic increase of MMP9 expression was shown in the ischemic side. rtPA treatment marked enhanced expression of both MMP2 and MMP9 in the ischemic and nonischemic side, which were attenuated by combination treatment of E2. B and C, densitometric analysis of expression of MMP2 (B) and MMP9 (C). The ratio was normalized to 100% of nonischemic hemisphere of controls (Ctl). ∗, p < 0.05 versus nonischemic side in controls. # and ##, p < 0.01 versus ischemic side in rtPA group.