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. 2010 Mar;332(3):1006–1012. doi: 10.1124/jpet.109.160937

Fig. 7.

Fig. 7.

A, E2 induces uteri hypertrophy in ovariectomized (Ctl) rats in both short-term chronic (E2 pellet) and acute treatment (E2 acute) paradigms. ∗, p < 0.01 versus Ctl; ∗∗, p < 0.01 versus Ctl and acute estrogen treatment. B, effect of chronic and acute E2 treatments in ischemic lesion volume at 24 h after embolic MCAO. A significant reduction of lesion volume was indicated upon short-term chronic E2 treatment (E2 pellet) but not acute treatment (E2 acute). ∗, p < 0.05 versus control (Ctl). C, effect of combination therapy of estrogen and rtPA in embolic MCAO model. rtPA was administered (10 mg/kg i.v.) at 0.5 h (rtPA 0.5h) or 3 h (rtPA 3h) after embolic MCAO. E2 or vehicle was administered subcutaneously at 3 h immediately before the administration of rtPA. ∗, p < 0.05: E2 versus vehicle; ∗∗, p < 0.05: rtPA (0.5h) versus vehicle.