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SNX-0723 is absorbed by the brain and causes Hsp70 induction in vivo. A, SNX-0723 is brain-permeable. Rats orally dosed with 10 mg/kg SNX-0723 reached maximal brain concentration at 6 h after dose with almost complete clearance by 24 h. B, SNX-0723 causes a 5-fold induction of Hsp70 in the rat brain after a single oral dose of 10 mg/kg.
