Fig. 4.

Effects of various muscarinic receptor agonists as pretreatment to 10 mg/kg cocaine. Abscissae, muscarinic agonist dose in mg/kg; “V” indicates vehicle. Ordinates, percentage cocaine-appropriate responses (top); response rate in responses per second (bottom). Data are groups means ± S.E.M. Group sizes: TBPB, n = 8. all other, n = 9. Exceptions to these group sizes are indicated when some mice failed to respond at a particular drug dose and were not tested on a higher dose, when applicable. *, p < 0.05; **, p < 0.01; ***, p < 0.001 versus saline.