Fig. 5.

Effects of muscarinic agonist pretreatments on the cocaine dose-effect function. Abscissae, cocaine dose in mg/kg; “Sal” indicates saline. Ordinates, percentage cocaine-appropriate responses (top); response rate in responses per second (bottom). Data are groups means ± S.E.M. Group sizes: oxotremorine and TBPB, n = 8; xanomeline, n = 9. Exceptions to these group sizes are indicated when some mice failed to respond at a particular drug dose. *, p < 0.05; **, p < 0.01 versus cocaine alone.