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Effects of xanomeline pretreatment in M1−/−M4−/− and wild-type mice. Abscissae, xanomeline dose in mg/kg; “V” indicates vehicle. Ordinates, percentage cocaine-appropriate responses (top); response rate in responses per second (bottom). Data are group means ± S.E.M. Group sizes: M1−/−M4−/−, n = 3; wild-type, n = 6. Exceptions to these group sizes are indicated when some mice failed to respond at a particular drug dose and were not tested on a higher dose.
