TABLE 1.
Pretreatment (dose) | A50 DAR | n/n | A50 Rate Reduction | n/n |
---|---|---|---|---|
Cocaine | 1.96 (1.46–2.64) | 29/29 | Not calculated | 4/29 |
Amphetamine | 0.33 (0.22–0.54) | 7/7 | Not calculated | 3/7 |
U-50488 | Not applicable | 0/6 | 9.32 (6.25–13.90) | 6/6 |
Scopolamine | 0.90 (0.29–2.76) | 4/8 | Not calculated | 3/8 |
Methylscopolamine | 4.46 (2.95–14.15) | 6/8 | 33.13 (20.34–53.95) | 5/8 |
n/n indicates the number of mice showing ≥50% reduction in %DAR and ≥50% reduction in response rates, respectively, over the number of mice tested.