TABLE 4.
Pretreatment-induced cocaine dose-effect function shifts
The dose of cocaine estimated to produce 50% DAR, as group mean of values calculated in each mouse (95% confidence interval), was significantly higher after all but the oxotremorine treatment, which produced a smaller, nonsignificant rightward shift. Fold shift indicates the A50 after pretreatment divided by the baseline A50, as group mean and 95% confidence interval of shifts calculated in each mouse.
| Pretreatment (dose) | A50 Cocaine Alone | A50 Pretreatment | Fold Shift | Mean Rate Decrease |
|---|---|---|---|---|
| Oxotremorine (0.032) | 2.06 (1.30–3.24) | 4.92 (2.96–8.16) | 3.4 (1.1–5.8) | −53% (−68 to −39%) |
| Xanomeline (1.0) | 1.22 (0.61–2.44) | 5.76 (3.36–9.88) a | 5.5 (2.8–8.3) | −28% (−45 to −10%) |
| Xanomeline (1.8) | 1.16 (0.69–1.94) | 5.32 (2.86–9.90) a | 7.0 (2.3–11.7) | −51% (−67 to −35%) |
| TBPB (32) | 1.43 (0.86–2.37) | 7.30 (4.04–13.20) a | 6.7 (4.3–9.1) | +6% (−15 to +5%) |
| Eticlopride (0.032) | 1.10 (0.78–1.74) | 4.39 (2.70–7.13) a | 5.4 (0.9–9.8) | −4% (−9 to +17%) |
| Eticlopride (0.1) | 1.10 (0.78–1.74) | 4.45 (2.15–9.21) a | 4.3 (2.6–6.1) | −70% (−87 to −53%) |
a
Nonoverlapping 95% confidence intervals relative to cocaine alone.