Fig. 6.

Fibrinolytic activity of circulating anti-GPA scFv/PA/mRBC complex in arterial thrombosis. A, fibrinolytic activity recovered in mouse blood samples obtained 45 min after intravenous injection of 4 mg/kg dose of anti-GPA scFv/PA fusion protein, 2 mg/kg PA or saline. n = 4 per group; p < 0.05. B, occlusive thrombi were formed in the carotid artery of mice by applying FeCl₃ to adventitia. Thirty minutes before injury 4 mg/kg dose of anti-GPA scFv/PA fusion protein, 2 mg/kg PA or saline were injected (intravenously jugular vein). Time of complete vessel occlusion was determined with Doppler ultrasound. Data shown as mean ± S.E.M.; n = 8 per group; p < 0.05.