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. 2010 Mar;332(3):1072–1080. doi: 10.1124/jpet.109.158113

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Copyright © 2010 by The American Society for Pharmacology and Experimental Therapeutics

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Fig. 4. — mRNA levels of the functional molecules of podocyte, nephrin (A) and podocin (B), in isolated glomeruli at 50 weeks of age. The levels of nephrin and podocin mRNA in vehicle-treated OLETF rats are significantly lower than those in vehicle-treated LETO rats. In OLETF rats, treatment with telmisartan or eplerenone partially attenuates the reductions in glomerular nephrin mRNA levels. Reductions in glomerular podocin mRNA levels also tend to be attenuated by telmisartan or eplerenone, but these changes do not reach statistically significant. Treatment with telmisartan + eplerenone prevents the reductions in glomerular nephrin and podocin mRNA levels, which are not significantly different from those in LETO rats. In contrast, treatment with hydralazine does not alter the levels of nephrin and podocin mRNA in OLETF rats. ∗, P < 0.05 versus LETO rats. †, P < 0.05; OLETF + vehicle versus OLETF + telmisartan, eplerenone, or telmisartan + eplerenone.