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. 2010 Mar;332(3):1072–1080. doi: 10.1124/jpet.109.158113

Fig. 5.

Fig. 5.

Glomerular mRNA levels of MR (A), Sgk-1 (B), collagen I (C), and α-SMA (D) at 50 weeks of age. The levels of MR, Sgk-1, collagen I, and α-SMA mRNA in vehicle-treated OLETF rats are significantly higher than those in vehicle-treated LETO rats. In OLETF rats, treatment with telmisartan changes neither MR nor Sgk-1 mRNA levels. However, treatment with eplerenone or telmisartan + eplerenone significantly decreases glomerular expression of MR and Sgk-1. Conversely, treatment with telmisartan, eplerenone or telmisartan plus eplerenone decreases glomerular mRNA levels of collagen I and α-SMA, changes that do not significantly differ among the groups. Treatment with hydralazine does not alter MR, Sgk-1, collagen I, and α-SMA mRNA levels in OLETF rats. ∗, P < 0.05 versus LETO rats. †, P < 0.05; OLETF + vehicle versus OLETF + telmisartan, eplerenone, or telmisartan + eplerenone.