TABLE 1.
Animal data at 50 weeks of age
| LETO + Vehicle | OLETF + Vehicle | OLETF + Telmisartan | OLETF + Eplerenone | OLETF + Telmisartan + Eplerenone | OLETF + Hydralazine | |
|---|---|---|---|---|---|---|
| No. | 10 | 12 | 12 | 12 | 12 | 12 |
| BW (g) | 500 ± 15 | 629 ± 25* | 602 ± 28* | 608 ± 23* | 611 ± 21* | 605 ± 29* |
| Right KW (g) | 1.31 ± 0.03 | 2.45 ± 0.13* | 1.92 ± 0.11*† | 1.96 ± 0.15*† | 1.86 ± 0.09*† | 2.28 ± 0.21* |
| Right KW/BW ratio (%) | 0.27 ± 0.02 | 0.38 ± 0.04* | 0.32 ± 0.03* | 0.32 ± 0.04* | 0.29 ± 0.04 | 0.35 ± 0.06* |
| PPBG (mg/dl) | 6 ± 2 | 14 ± 3* | 13 ± 2* | 13 ± 4* | 13 ± 3* | 14 ± 4* |
| Plasma sodium (mEq/l) | 144 ± 5 | 145 ± 8 | 143 ± 6 | 142 ± 5 | 141 ± 6 | 144 ± 8 |
| Plasma potassium (mEq/l) | 4.2 ± 0.3 | 4.4 ± 0.3 | 4.8 ± 0.5 | 4.9 ± 0.4 | 4.9 ± 0.6 | 4.8 ± 0.6 |
| Plasma Cr (mg/dl) | 0.39 ± 0.03 | 0.41 ± 0.05 | 0.41 ± 0.04 | 0.40 ± 0.03 | 0.39 ± 0.05 | 0.43 ± 0.06 |
| Plasma aldosterone (pg/ml) | 281 ± 44 | 368 ± 61 | 216 ± 49† | 873 ± 102*† | 726 ± 74*† | 383 ± 48 |
BW, body weight; KW, kidney weight.
*
P < 0.05 vs. LETO + vehicle.
†
P < 0.05; OLETF + vehicle vs. OLETF + telmisartan, eplerenone, or telmisartan + eplerenone.