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. 2010 Mar;332(3):1136–1145. doi: 10.1124/jpet.109.161109

Fig. 5.

Fig. 5.

Potential mechanisms of action of antigenic peptide or BPI molecule in the suppression of EAE. Mature dendritic cells present processed antigenic peptides to naive T cells to generate Th1 and/or Th17 cells. BPI molecule binds simultaneously to MHC-II and ICAM-1 on mature dendritic cells and prevents the formation of the immunological synapse. As a result, BPI molecule inhibits the formation of Th1 and generates Th2 cells. Immature dendritic cells can also present a soluble antigenic and BPI molecule to naive T cells to produce IL-10-producing T-regs. Produced IL-10 suppresses the generation of Th1 and Th17 cells, resulting in the suppression of the disease.