TABLE 1.
List of peptides used in the present study
BPI is composed of antigen epitope peptide (PLP139-151), varying spacers, and LABL peptide (CD11a237-246), where Acp in the spacer represents ϵ-aminocaproic acid. The peptides are capped at both ends, i.e., N-terminal acetylated (Ac−) and C-terminal amidated (−NH2).
| Peptide | Sequence |
|---|---|
| PLP139-151 | HSLGKWLGHPDKF |
| LABL (CD11a237-246) | ITDGEATDSG |
| Ac-PLP-BPI-NH2-2 | Ac-HSLGKWLGHPDKF-(AcpGAcpGAcp)2-ITDGEATDSG-NH2 |
| Ac-LABL-PLP-NH2 | Ac-ITDEATDSG-AcpGAcpGAcp-HSLGKWLGHPDKF-NH2 |
| Ac-PLP-BPI-PEG3 | Ac-HSLGKWLGHPDKF-Acp(C2H5O)3Acp-ITDGEATDSG-NH2 |
| Ac-PLP-BPI-PEG6 | Ac-HSLGKWLGHPDKF-(C2H5O)3-G-(C2H5O)3-ITDGEATDSG-NH2 |
| Ac-PLP-BPI-PEG6SC | Ac-SLKHGGLWPHKDF-(C2H5O)3-G-(C2H5O)3-TDGITSGEDA-NH2 |