Fig. 1.

Change in body weight of mice after DSS induction and resveratrol treatment. C57BL/6 mice were given no treatment (Δ, control), resveratrol (100 mg/kg b.wt.) alone suspended in 100 μl of distilled water by oral gavage (□, RES), DSS alone (3%) in drinking water (●, DSS+vehicle), or a combination of DSS and resveratrol (DSS+RES) at 10 (⧫), 50 (☒), and 100 (○) mg/kg b.wt. of resveratrol for 14 days. After 7 days, DSS was replaced with a water cycle (ad libitum) for another 7 days. The body weight of the mice was recorded daily. Changes in body weight were expressed as a percentage of the weight minus the change in weight divided by the weight before the onset of colitis at day 1 (current weight-weight of previous day/day 1 weight). The statistical significance between values of each group was assessed by Student's t test. Data represent the mean of three experiment involving six mice per group. Asterisks indicate statistically significance difference (P < 0.01) between DSS+vehicle and DSS+100 mg/kg RES-treated mice.