Fig. 5.

Histological characterization of DSS-induced colitis after resveratrol treatment. Histological sections of colons from the four groups of mice were presented (as described in Fig. 1). DSS+vehicle-treated mice showed significant lymphocyte infiltration and distortion of glands, whereas DSS+resveratrol-treated mice showed colon lumen having markedly decreased lymphocyte infiltration. Other pathologic changes during DSS-induced colitis included diffuse leukocyte infiltrates, distorted crypts, and thickening of the LP in the area of distorted crypts in the colon. These changes were significantly reversed in DSS+resveratrol (100 mg/kg) groups.