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. 2010 Mar;332(3):1100–1106. doi: 10.1124/jpet.109.161232

Fig. 7.

Fig. 7.

Effects of PLTP inhibitors on apoB secretion in mouse primary hepatocytes. a, apoB secretion in mouse primary hepatocytes isolated from wild-type and PLTP-deficient mice. ApoB secretion was measured as described under Materials and Methods. Data are the average of triplicates ± S.D. (*, p < 0.01 compared with wild type). Representative image is shown in inset. b and c, effects of compound A on apoB secretion in hepatocytes isolated from wild-type mice (b) or PLTP-deficient mice (c). Cells were labeled with [35S]methionine/cysteine in the presence of vehicle (DMSO) or 30 μM compounds for 4 h. Medium and cells were collected to detect labeled apoB as described under Materials and Methods. Data are average of triplicate experiments ± S.D. (p < 0.01 compared with vehicle group). Representative images are shown in insets.