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Correlation of in vitro melanin (S. officinalis) binding of β-blockers with tissue partition coefficients in intact choroid-RPE (A and B), homogenized choroid-RPE (C and D), and solute lipophilicity (E and F). Melanin binding capacities correlated better than binding affinities. Results are expressed as the mean of n = 5 for tissue partitioning and mean of n = 3 for melanin binding.
