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. Author manuscript; available in PMC: 2010 Oct 1.
Published in final edited form as: Matrix Biol. 2009 Jul 28;28(8):463–469. doi: 10.1016/j.matbio.2009.07.005

Table 1.

Ki(app) values a (nM) for TIMP-3 and N-TIMP-3 inhibition of selected MMPs.

Kashiwagi et al. E. coli-expressed
N-TIMP-3		 Current study E. coli-expressed
N-TIMP-3		 Mammalian expressed
N-TIMP-3		 Mammalian expressed
TIMP-3
MMP-1cat 1.2 0.8 ± 0.4 0.9 ± 0.6 1. 1 ± 0.6
MMP-2 4.3 1.3 ± 0.5 0.9 ± 0.3 <0.1
MMP-2cat ND 0.8 ± 0.1 1.0 ± 0.3 0.9 ± 0.3
MMP-3cat 66.9 11.1 ± 5.0 9.1 ± 3.3 1.0 ± 0.4
a

Ki(app) given as mean ± standard deviation (n=4-6).