. Author manuscript; available in PMC: 2010 Oct 1.

Published in final edited form as: Matrix Biol. 2009 Jul 28;28(8):463–469. doi: 10.1016/j.matbio.2009.07.005

Table 2.

K_i values (nM) ^a for mammalian-expressed TIMP-3 and N-TIMP-3 inhibition of ADAMTS-4 and ADAMTS-5.

	N-TIMP-3	TIMP-3		N-TIMP-3	TIMP-3
ADAMTS5-1	0.13 ± 0.06	0.63 ± 0.17
ADAMTS5-2	0.35 ± 0.03	0.72 ± 0.17	ADAMTS4-1	0.13 ± 0.06	0.22 ± 0.15
ADAMTS5-3	0.29 ± 0.08	1.00 ± 0.39	ADAMTS4-2	0.18 ± 0.02	0.22 ± 0.07
ADAMTS5-4	0.40 ± 0.18	1.13 ± 0.37	ADAMTS4-3	0.10 ± 0.01	0.40 ± 0.07
ADAMTS5-5	1.01 ± 0.45	1.17 ± 0.33	ADAMTS4-4	0.64 ± 0.15	0.51 ± 0.21

K_i values given as mean ± standard deviation (n=4-6).