Table 2.
Results of rechallenge of ferrets with a lethal dose of homologous H5N1 after earlier oseltamivir treatment; all three rechallenged ferrets survived with no clinical signs of disease; reproduced from Govorkova et al.37 with permission
| Range of pre-challenge HI titres (3 weeks after initial inoculation, expressed as reciprocal values) |
|||||
|---|---|---|---|---|---|
| Virus | Oseltamivir regimen used to treat initial infection | Rechallenge virus dose (EID50/ferret) | A/Vietnam/1203/04 | A/HK/213/03 | A/Turkey/15/06 |
| A/Vietnam/1203/04 | 25 mg/kg/day (24 h delay) | 102 | 20–40 | 80–160 | not tested |
| A/Turkey/15/06 | 10 mg/kg/day (24 h delay) | 107 | 20–40 | 320–640 | 160–320 |
EID50, 50% egg infectious dose; HI, haemagglutinin inhibition.