Table 3.
Statin drug summary
| Drug | Usual dose in mg for 30%–40% reduction in LDL56 | Administration guidelines37–42 | Metabolism37–42 |
|---|---|---|---|
| Atorvastatin (Lipitor®) | 10 | po w or w/o food | P450 CYP 3A4 |
| Simvastatin (Zocor®) | 20–40 | po in evening | P450 CYP 3A4 |
| Pravastatin (Pravachol®) | 40–80 | po w or w/o food at anytime; when given with bile-acid-binding resin, give pravastatin 1 hour before or 4 hour after resin | Isomerization, hydroxylation, oxidation, conjugation |
| Lovastatin (Mevacor®) | 40–80 | po take with evening meal for maximum bioavailability | Hydrolysis, P450 CYP 3A4 |
| Fluvastatin (Lescol®) | 80 | po take w or w/o food in the evening; if taken with bile-acid resin, administer fluvastatin at bedtime at least 2 hours after resin | 75% via P450 CYP 2C9, 5% via 2C8, 20% via 3A4 |
| Rosuvastatin (Crestor®) | 5 | po w or w/o food at any time; if taken with aluminum and magnesium combination antacid, take antacid 2 hour after rosuvastatin | P450 CYP 2C9 |
Abbreviations: LDL, low-density lipoprotein; po, oral; w, with; w/o, without.