Fig. 2.

Transcriptional profiling analyses in R, S, and G3 mosquitoes, including genes involved in immune reactions (blue), redox metabolism, and detoxification (red), genes encoded by the mitochondrial genome (green), and others (black) functioning in the mitochondria or are involved in other oxidoreductive processes. (A and B) Differences in gene expression between R and S (A, ΔR-S) and R and G3 (B, ΔR-G3) female mosquitoes after blood feeding on healthy mice (BF) or mice infected with P. berghei (INF). Gene expression was assessed at 3, 24, and 36 h after blood feeding by using sugar-fed mosquitoes as reference. (C) Direct comparison of gene expression in infected and blood-fed-susceptible (S, G3) mosquitoes. (D) Expression profiling of A. gambiae cells treated with H₂O₂ (9) and assayed 1, 4, 12, 18, and 24 h after challenge. Naïve cells were used as reference. Full annotation of the presented genes can be found in Table 1, which is published as supporting information on the PNAS web site.