Fig. 5.

Spiky signaling in CTLs stimulated with low antigen concentration. (A and B) Typical calcium mobilization patterns are depicted: high concentration patterns (A) and low concentration patterns (B). (C) The ensemble average of the calcium flux over time is shown. (D) The correlation of spikiness and mean calcium flux is shown. (E) An examplatory fitting of a smooth curve to a time series is given. (F) The temporal evolution of the ensemble average of the signal pattern spikiness is depicted for both specific peptide concentrations.