Table 2.

Adverse Events by Dose Level

Grade 1 Adverse Event	N (%)	2.5 μg	25 μg	100 μg
Number of patients	36	11	16	9
Nausea	8 (22)	2 (18)	3 (19)	3 (33)
Fatigue	7 (19)	3 (27)	2* (12)	2 (22)
Headache	7 (19)	3 (27)	2 (12)	2 (22)
Constipation	5 (14)	2 (18)	2 (12)	1 (11)
Asthenia	4 (11)	1 (9)	1 (6)	2 (22)
Pyrexia	4 (11)	1 (9)	1 (6)	1 (11)
Visual change	3 (8)		1** (6)	2** (12)
Zoster reactivation	1 (3)			1 (11)

* Grade 2, one patient

** Fleeting, not associated with abnormal ophthalmologic exam