Table 1.
Systolic blood pressure and echocardiography data in diabetic Goto-Kakizaki (GK) rats and non-diabetic Wistar (W) rats 12 weeks post myocardial infarction (MI) or Sham operation, (d) denotes diastole and (s) systole.
| W Sham (n = 9) |
GK Sham (n = 8) |
W + MI (n = 9) |
GK + MI (n = 8) |
|
|---|---|---|---|---|
| Systolic blood pressure (mmHg) | 144 ± 7.9 | 149 ± 6.2 | 135 ± 5.4* # | 131 ± 14* # |
| Anterior wall thickness (d), (mm) | 1.8 ± 0.2 | 1.8 ± 0.3 | 1.3 ± 0.6 | 1.5 ± 0.7 |
| Anterior wall thickness (s), (mm) | 3.1 ± 0.1 | 3.1 ± 0.1 | 1.7 ± 0.4* # | 1.9 ± 0.4* # |
| LV inner diameter (d), (mm) | 8.6 ± 0.5 | 7.9 ± 0.6 | 10.4 ± 1.1* # | 10.0 ± 1.7# |
| LV inner diameter (s), (mm) | 5.0 ± 0.2 | 4.4 ± 0.3 | 8.5 ± 0.7* # | 8.3 ± 0.8* # |
| Posterior wall thickness (d), (mm) | 1.9 ± 0.2 | 2.1 ± 0.2 | 2.3 ± 0.4 | 2.1 ± 0.6 |
| Posterior wall thickness (s), (mm) | 3.1 ± 0.1 | 3.2 ± 0.1 | 2.9 ± 0.2 | 2.5 ± 0.2 |
| End-diastolic volume, (ml) | 1.4 ± 0.2 | 1.1 ± 0.2 | 2.3 ± 0.6* # | 2.2 ± 0.9* # |
| End-systolic volume, (ml) | 0.3 ± 0.03 | 0.2 ± 0.03 | 1.52 ± 0.27* # | 1.4 ± 0.3* # |
| Heart rate, (min -1) | 341 ± 26 | 360 ± 29 | 346 ± 19 | 302 ± 60# |
| Ejection fraction (%) | 77.9 ± 1.9 | 80.5 ± 2.3 | 39.7 ± 7.7* # | 41.6 ± 6.9* # |
| Fractional shortening (%) | 42.3 ± 1.7 | 45.3 ± 2.7 | 18.9 ± 4.2* # | 19.1 ± 3.9* # |
| Cardiac Output (ml/min) | 368 ± 18.8 | 321 ± 23.7 | 258 ± 39.6* | 228 ± 21.9* |
The data is presented as means ± SEM.
* denotes P < 0.05 vs. W Sham, #P < 0.05 vs. GK Sham, †denotes P < 0.05 vs. W + MI.