Fig. 2.

Body weight analyses and survival rate of treated mice. Influence of 12 months of treatment on body weight of male (A) and female (B) mice. (C) Survival rate of APP23 and nontransgenic littermate control mice at 15, 18, and 21 months of age. All mice were treated for a 3-month period (short-term treatment) starting at 12, 15, and 18 months of age, respectively. APP23 mice showed a significant reduced life duration, which was not observed in the Cu-treated group. Cu had no detrimental effect on survival of nontransgenic control mice. APP23, APP transgenic mice (gray bars); wt, nontransgenic littermate controls (black bars).