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Cu levels in TgCRND8 brain. At 3–5 months the reduction in brain Cu was nonsignificant. By 9–10 months of age the difference was significant (P < 0.05; t test; n = 11 non-Tg and 7 TgCRND8 at 3–5 months; n = 7 non-Tg and 10 TgCRND8 at 9–10 months). No significant difference in brain Zn (Right) was found. Asterisks in this and subsequent figures indicate where pairwise t test comparisons or Fisher's LSD post hoc test were significant. **, P < 0.01.
