Effect of peripherally administered rAAV1-Acrp30 or rAAV5-Acrp30 on glucose tolerance (GT) in DIO female rats. □, DIO control rats injected with rAAV-GFP (n = 10) and fed the HF; ○, control rats injected with rAAV-GFP (n = 6) and fed the ND; ▴, rats injected with rAAV1-Acrp30 vector (n = 6) and fed the HF; ♦, rats injected with rAAV5-Acrp30 vector (n = 6) and fed the HF. IP GTT was conducted at week 28 after treatment (arrows in Fig. 1 A and C). *, P < 0.05, when compared with DIO control rats.