Fig. 5.

Diagram summarizing EIM data. LPS acts through toll-like receptor and initiates the heart's response to SIRS. Each spiral represents ≈50 genes or EST that are significantly changed in our microarray studies at P ≥ 0.01. Green spirals denote the number of genes that are common to the 6- and 24-h transcriptional response; they characterize a possible stereotypic response of the innate immune system in the heart. Red and black spirals designate genes that have a fold change of 2 or higher and 5 or higher, respectively. There is a small divergence in the response of the RV and LV at 6 h, which is intensified at 24 h. Note that the expansion of the transcriptional response in the heart at 24 h is more intense in the RV (it has more red and black spirals), the site for EIM. Hypothetically, the exacerbation of EIM would lead to death and the termination of the inflammatory process would result in recovery. R, right ventricle; L, left ventricle.