Table 1. χ2 analyses of gene changes after LPS treatment.
Up-regulated genes and time*
|
FC at 24 h in RV and LV*
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FC at 6 h in RV and LV†
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Large FC at 24 h in RV and LV*
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Large FC at 6 h in RV and LV‡
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---|---|---|---|---|---|---|---|---|---|---|
With treatment effect | Entire data set | Treatment FC < ± 2 | Treatment FC ≥ ± 2 | Treatment FC < ± 2 | Treatment FC ≥ ± 2 | Treatment FC < ± 5 | Treatment FC ≥ ± 5 | Treatment FC < ± 5 | Treatment FC ≥ ± 5 | |
6 h | 139 | 3,903 | ||||||||
24 h | 423 | 3,758 | ||||||||
Right | 375 | 174 | 183 | 76 | 505 | 44 | 246 | 13 | ||
Left | 476 | 73 | 203 | 56 | 531 | 18 | 253 | 6 |
In this table, we report five separate χ2 analyses (first through fifth columns). These show associations between transcription changes and time or side of heart ventricle. The analyses revealed that significantly more genes are upregulated at 24 h than at 6 h after LPS treatment (first column). Significantly more genes had fold-change ≥ 2 in the RV at 24 h (second column) and at 6 h (third column). The proportion of genes with treatment fold changes ≥ 5 was significantly higher in the RV when compared to the LV at 24 h (fourth column), but not at 6 h (fifth column). FC, fold change.
P < 0.0001
P = 0.045
P = 0.101