Table 1.
Receptor | Ligand | Proliferation | Differentiation/Apoptosis | Lipid synthesis | Cytokine synthesis |
Peptide Hormone Receptors | |||||
CRHR1 | CRH, urocortin | ↓ | ↑ | ↑ | |
CRHR2 | |||||
MC-1R | α-MSH | ↓ | |||
MC-5R | α-MSH | ↑ | |||
OPR | β-endorphin | ↑ | |||
VPAC | VIP, NY, CGRP | ↑ | |||
CBR1 | ↑ | ||||
CBR2 | Endocannabinoids | ↓ | |||
Histamine-1R | Histamine, antihistaminics | ↓ (squalene) | |||
IGF-IR | IGF-I, insulin | ↑ | |||
GHR | GH | ↑ | |||
Nuclear Receptors | |||||
AR | Androgens | ↑ | ↔ | ||
PR | Progesterone | ||||
ER-α | Estrogens | ||||
ER-β | Estrogens | ↑ (polar lipids) | |||
RARα | Tretinoin | ↓ | |||
RARγ | Tretinoin | ↓ | |||
RXRα | Retinoids | ↑ | ↑ | ||
RXRβ | |||||
RXRγ | |||||
VDR | Vit. D | ↑ | ↓ | ↓ | |
PPARα | LTB4 | ↓ | ↑ | ||
PPARγ | Linoleic acid, 15d-PGJ2, thioglitazones, WY 14643 | ↑ | |||
LXR-α | 22(R)-hydroxycholesterol, TO901317 | ↓ | ↑ | ||
LXR-β | |||||
VR | Capsaicin | ↓ | |||
Other Receptors | |||||
FGFR2b | |||||
EGF | HGF | ||||
c-MET | |||||
CD14 | ↑ | ||||
TLR-2 | LPS | ↑ | |||
TLR-4 | LTA | ↑ | |||
TLR-6 | ↑ |