Table 2.
Comparison of in vivo left ventricular functional parameters in lean control (LC) and zucker diabetic fatty (ZDF) rats at 16 and 36 weeks of age
| Heart rate (bpm) | End systolic pressure (mmHg) | End diastolic pressure (mmHg) | End systolic volume (μl) | End diastolic volume (μl) | Cardiac output (ml/min) | Stroke volume (μl) | Volume @ Min & Max dP/dt (μl) | Min & Max dV/dt (μl/sec) | |
| 16 weeks of age | |||||||||
| Lean Control | 282 ± 10 | 121 ± 3 | 9 ± 1 | 196 ± 22 | 306 ± 23 | 31 ± 5 | 110 ± 16 | 206 ± 25 | −2134 ± 400 |
| 301 ± 24 | 2778 ± 330 | ||||||||
| ZDF | 282 ± 35 | 117 ± 16 | 10 ± 1 | 200 ± 13 | 355 ± 4* | 44 ± 7 | 155 ± 16* | 227 ± 17 | −2268 ± 372 |
| 364 ± 19* | 3251 ± 284 | ||||||||
| 36 weeks of age | |||||||||
| Lean Control | 265 ± 10 | 124 ± 5 | 7 ± 1 | 299 ± 16 | 367 ± 12 | 36 ± 3 | 138 ± 13 | 238 ± 19 | −3267 ± 200 |
| 350 ± 12 | 3750 ± 540 | ||||||||
| ZDF | 235 ± 10 | 125 ± 8 | 10 ± 1* | 380 ± 34* | 504 ± 34* | 29 ± 2 | 123 ± 5 | 394 ± 35* | −2643 ± 325* |
| 497 ± 35* | 2819 ± 260* |
Values are presented as mean ± SEM. *denotes p < 0.05 versus age-matched LC rats. n ≥ 6 per group. dP/dt = an indicator of myocardial contractility (maximum or minimum first derivative of LV pressure) dV/dtmax = left ventricular ejection rate during systole, and dV/dtmin = peak rate of passive diastolic filling of the left ventricle.