Table 1. Effect of deep brain stimulation in patients with obsessive-compulsive disorders.

Reference(s)	Patients	Stimulation site	Effect*
Nuttin et al., 2003 (1)Gabriels et al., 2003 (4) Nuttin et al., 1999 (5) Nuttin et al., 2003 (6) van Laere et al., 2006 (7) Cosyns et al., 2003 (8) Nuttin et al., 2003 (9)	6	Anterior limb of internal capsule, bilateral	Observation for up to 20 months:Reduction in Y-BOCS score: 3 full response 1 partial response 2 no response
Abelson et al., 2005 (2)	4	Anterior limb of internal capsule, bilateral	Observation 4 to 23 months:Reduction in Y-BOCS score: 2 full response 2 no response
Greenberg et al., (2006) (10)	10	Anterior limb of internal capsule (7/10), caudal part of nucleus accumbens (8/10), bilateral (8/10)	Observation for 36 months:(data for 8 patients were evaluated): Significant reduktion in Y-BOCS score: 4 full response 2 partial response 2 no response
Mallet et al., (2008) (3)	16	Subthalamic nucleus, bilateral	Observation for 3 months:Randomized controlled comparison of on-off (off-on) condition: Significant reduction in Y-BOCS score after „on-stimulation“; high rate of adverse effects
Huff et al., (in press) (11)	10	Nucleus accumbens, right—uniliteral	Observation for 12 months:Significant reduction in Y-BOCS score: 1 full response 4 partial response 5 no response

^*Full response: >35% reduction in Yale-Brown Obsessive Compulsive Scale (Y-BOCS) score; partial response: <35% >25% reduction in Y-BOCS score; no response: <25% reduction in Y-BOCS score (from e13)