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. 2010 Mar 8;188(5):693–706. doi: 10.1083/jcb.200905024

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© 2010 Januschke and Gonzalez

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Figure 7. — The role of the microtubule network in the orientation of asymmetric cell division in Drosophila NBs. (A) Under normal conditions, the apical position of the main MTOC is maintained through the cell cycle and passed on from mother to daughter NB (1 and 2), polarity orientation is retained in consecutive mitoses, and the small differentiating cells (GMCs) are delivered in a cluster (3). (B and C) Under microtubule depolymerization conditions, the interphase aster is disassembled, and the cortical attachment of the apical centrosome is lost. If microtubule dynamics are restored during interphase, the memory of cortical polarity orientation is often unaffected (B, 1, asterisk). However, if microtubule-depolymerizing conditions are kept until the cell enters mitosis, the orientation of cortical polarity is randomized (B, 2), and once microtubule dynamics are restored, asymmetric cell division takes place along the new, ectopic axis of cortical polarity (C, 1). This situation results in the ectopic delivery of a GMC, the relocation of the interphase aster of the NB (C, 2), and the resetting of the axes of cortical polarity and asymmetric cell division orientation to the new ectopic orientation (C, 3). (D) In different mutant conditions that affect the assembly or the stability of the interphase asters, the memory of polarity orientation is partially lost (1 and 2) and daughter cells are not clustered (3).