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. 2010 Mar 8;188(5):735–749. doi: 10.1083/jcb.200910099

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© 2010 Martin et al.

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Figure 6. — Sensitizing AJs disrupts intracellular connections between the actomyosin cytoskeleton and the plasma membrane. (A) Scanning EM of ventral furrows in wild-type embryos. (B and C) Scanning EM of arm^M/Z embryos. Membrane tethers extend between dissociated cells (B) and across epithelial tears (C). (D) Myosin II localizes to regions of membrane blebs that are interconnected by membrane tethers. Images of apical myosin II (red, myosin-mCherry), apical membrane (green, Spider-GFP), and subapical membrane (purple) in live armRNAi embryos. (E) Model: Lower adhesion in arm mutants causes higher tension per adhesive structure, leading to the rupture of fiber–AJ connections. Bars: (A–C) 5 µm; (D) 10 µm.