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A. DSC thermograms between 20–105 °C of abatacept in sodium phosphate buffer at pH 6 (dotted) and pH 7.5 (solid). B. Refolding of first thermal transition between 15–65 °C of abatacept in 10 mM sodium phosphate, 25 mM NaCl, at pH 7.5. First heat-cool-heat cycle yields 51% reversibility (solid to dashed) and second cycle yields 96.5% reversibility (dashed to dotted).
