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Anti-CD4 aptamer mediated small interfering (si)RNA delivery. Schematic of a dimer of the chimeric phage (p)RNA-CD4 aptamer and chimeric pRNA-siRNA. The anti-CD4 aptamer or siRNAs were non-covalently joined via phi29 RNAs containing complementary loop domains. Through interactions of the interlocking left and right loops, chimeric phi29 RNAs could be fabricated into the dimers shown as an example.
